The Cognitive Revolution · Thursday, October 1, 2026
Daniel McKinnon explains that Gamo Labs uses AI to re-analyze complex genetic cases that traditional labs have left unresolved. The majority of these cases result in 'variants of uncertain significance' (VUS), and their AI approach aims to provide clearer diagnoses by analyzing these variants more deeply and performing functional studies.
“The majority of them end up in what's called a V.U.S. state. So it's a variant of uncertain significance.”
“And you need to get six points or more to be bumped into the likely pathogenic category. And that unlocks a lot of treatment options insurance options like just let's say it's like good to be either benign or likely pathogenic it's very bad to be in this kind of intermediate stage and if you are in this intermediate stage in a vus you can do two things to get a diagnosis”
“So we basically bought what was remaining of Arpeggio, hired four people on the team, and very quickly pivoted to creating this basically like RL data from real world with biology experiments.”